Impact of ultra-low tidal volume ventilation on 1-year functional outcome in COVID-19 ARDS patients. A long-term follow-up analysis of a randomized controlled trial.

ABSTRACT:

Background

Ultra-low tidal volume ventilation (ULTV) aims to minimize ventilator-induced lung injury in acute respiratory distress syndrome (ARDS), but is associated with an increase in arterial carbon dioxide (PaCO₂). This follow-up study aimed to evaluate whether ULTV impacted long-term pre-specified secondary outcomes in the VT4COVID trial.

Methods

VT4COVID was an open-label multicenter randomized controlled superiority trial performed in ten French intensive care units. Eligible patients were COVID-19 ARDS patients with arterial oxygen pressure (PaO₂) over inspired oxygen fraction (FiO₂) ≤ 150 mmHg, randomized to ULTV with tidal volume (VT) 4 mL.kg^- 1 predicted body weight (PBW), or low VT ventilation (LTV) with VT 6 mL.kg

SUBMITTER: Richard JC 

PROVIDER: S-EPMC13647660 | biostudies-literature | 2026 Jul

REPOSITORIES: biostudies-literature