Prognostic value of liver histology in steatotic liver disease: a systematic literature review and meta-analysis.

ABSTRACT: Aim: Metabolic dysfunction-associated steatohepatitis (MASH) and steatotic liver disease (MASLD) are progressive liver conditions that can lead to serious long-term outcomes and adverse clinical events. Histologic liver fibrosis is an accepted short-term surrogate end point used in pivotal clinical trials supporting conditionally approved MASH therapies. This study aimed to synthesize up-to-date published associations between histologic liver fibrosis and clinical outcomes, including several novel syntheses. Materials & methods: A systematic literature review identified studies of MASH ± MASLD patients published January 2014 to November 2024 from Ovid MEDLINE^®, Embase and grey literature. Studies reporting hazard ratios (HRs) comparing the risk of relevant major ad

SUBMITTER: Barritt AS 

PROVIDER: S-EPMC13648052 | biostudies-literature | 2026 Oct

REPOSITORIES: biostudies-literature