Pregenomic RNA is required for efficient incorporation of pol polyprotein into foamy virus capsids.

ABSTRACT: The foamy virus (FV) Pol polyprotein is translated independently of Gag from a spliced mRNA. This method of expression raises the question of how Pol is associated with the viral particle. Using a transient FV vector transfection system, it is shown that pregenomic RNA is required for efficient virion incorporation of functionally active Pol and that protein-protein interactions of Pol with Gag are not sufficient to complete particle assembly.

SUBMITTER: Heinkelein M 

PROVIDER: S-EPMC136505 | biostudies-literature | 2002 Oct

REPOSITORIES: biostudies-literature