PH-modulating binary hydrogen-bonded organic frameworks accelerate diabetic wound healing.

ABSTRACT: Diabetic foot ulcers have become an increasingly serious clinical problem, in which wound pH dysregulation and infection lead to impaired healing. To improve this situation, we propose a fabric coated with a binary hydrogen-bonded organic framework (SMU-8@W) to enhance wound healing efficiency. Specifically, the hydrogen-bonded organic framework (SMU-8) not only suppresses wound infection through its high photodynamic activity but also guides a "near-neutral-weakly acidic-near-neutral" pH transition at the wound site, thereby modulating the wound microenvironment. Moreover, SMU-8@W exhibits favorable hemostatic performance (BCI = 21.19 ± 2.52%), moisture permeability (5874.20 ± 196.03 g·m⁻²·d⁻¹), biosafety, and long-term stability, effectively managing wound exudate and alleviating inflamm

SUBMITTER: Sun J 

PROVIDER: S-EPMC13651154 | biostudies-literature | 2026 Jun

REPOSITORIES: biostudies-literature