Selection for human immunodeficiency virus type 1 recombinants in a patient with rapid progression to AIDS.

ABSTRACT: Although human immunodeficiency virus type 1 (HIV-1) recombinants have been found with high frequency, little is known about the forces that select for these viruses or their importance to pathogenesis. Here we document the emergence and dynamics of 11 distinct HIV-1 recombinants in a man who was infected with two subtype B HIV-1 strains and progressed rapidly to AIDS without developing substantial cellular or humoral immune responses. Although numerous frequency oscillations were observed, a single recombinant lineage eventually came to dominate the population. Numerical simulations indicate that the successive recombinant forms displaced each other too rapidly to be explained by any simple model of random genetic drift or sampling variation. All of the recombinants, including several res

SUBMITTER: Liu SL 

PROVIDER: S-EPMC136598 | biostudies-literature | 2002 Nov

REPOSITORIES: biostudies-literature