In vitro activity of DX-619, a novel des-fluoro(6) quinolone, against a panel of Streptococcus pneumoniae mutants with characterized resistance mechanisms.

ABSTRACT: The in vitro activities of DX-619 and four other quinolones were compared against Streptococcus pneumoniae mutants that contained a variety of alterations within the quinolone resistance-determining regions. DX-619 was the most potent quinolone and was least affected by the mutations.

SUBMITTER: Wickman PA 

PROVIDER: S-EPMC1366926 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature