Transcriptome profiling of Shewanella oneidensis gene expression following exposure to acidic and alkaline pH.

ABSTRACT: The molecular response of Shewanella oneidensis MR-1 to variations in extracellular pH was investigated based on genomewide gene expression profiling. Microarray analysis revealed that cells elicited both general and specific transcriptome responses when challenged with environmental acid (pH 4) or base (pH 10) conditions over a 60-min period. Global responses included the differential expression of genes functionally linked to amino acid metabolism, transcriptional regulation and signal transduction, transport, cell membrane structure, and oxidative stress protection. Response to acid stress included the elevated expression of genes encoding glycogen biosynthetic enzymes, phosphate transporters, and the RNA polymerase sigma-38 factor (rpoS), whereas the molecular response to alkaline pH w

SUBMITTER: Leaphart AB 

PROVIDER: S-EPMC1367224 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature