Spatial propagation and localization of blood coagulation are regulated by intrinsic and protein C pathways, respectively.

ABSTRACT: Blood coagulation in vivo is a spatially nonuniform, multistage process: coagulation factors from plasma bind to tissue factor (TF)-expressing cells, become activated, dissociate, and diffuse into plasma to form enzymatic complexes on the membranes of activated platelets. We studied spatial regulation of coagulation using two approaches: 1), an in vitro experimental model of clot formation in a thin layer of plasma activated by a monolayer of TF-expressing cells; and 2), a computer simulation model. Clotting in factor VIII- and factor XI-deficient plasmas was initiated normally, but further clot elongation was impaired in factor VIII- and, at later stages, in factor XI-deficient plasma. The data indicated that clot elongation was regulated by factor Xa formation by intrinsic tenase, wherea

SUBMITTER: Panteleev MA 

PROVIDER: S-EPMC1367302 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature