Alpha-gliadin genes from the A, B, and D genomes of wheat contain different sets of celiac disease epitopes.

ABSTRACT:

Background

Bread wheat (Triticum aestivum) is an important staple food. However, wheat gluten proteins cause celiac disease (CD) in 0.5 to 1% of the general population. Among these proteins, the alpha-gliadins contain several peptides that are associated to the disease.

Results

We obtained 230 distinct alpha-gliadin gene sequences from severaldiploid wheat species representing the ancestral A, B, and D genomes of the hexaploid bread wheat. The large majority of these sequences (87%) contained an internal stop codon. All alpha-gliadin sequences could be distinguished according to the genome of origin on the basis of sequence similarity, of the average length of the polyglutamine repeats, and of the differences in the presence of four peptides that have been identified as T ce

SUBMITTER: van Herpen TW 

PROVIDER: S-EPMC1368968 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature