Common and distinctive features of GNRA tetraloops based on a GUAA tetraloop structure at 1.4 A resolution.

ABSTRACT: GNRA tetraloops (N is A, C, G, or U; R is A or G) are basic building blocks of RNA structure that often interact with proteins or other RNA structural elements. Understanding sequence-dependent structural variation among different GNRA tetraloops is an important step toward elucidating the molecular basis of specific GNRA tetraloop recognition by proteins and RNAs. Details of the geometry and hydration of this motif have been based on high-resolution crystallographic structures of the GRRA subset of tetraloops; less is known about the GYRA subset (Y is C or U). We report here the structure of a GUAA tetraloop determined to 1.4 A resolution to better define these details and any distinctive features of GYRA tetraloops. The tetraloop is part of a 27-nt structure that mimics the universal sar

SUBMITTER: Correll CC 

PROVIDER: S-EPMC1370402 | biostudies-literature | 2003 Mar

REPOSITORIES: biostudies-literature