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The Noc proteins involved in ribosome synthesis and export contain divergent HEAT repeats.

ABSTRACT: The Noc1-4p proteins were previously reported to be involved in intranuclear and nucleocytoplasmic transport of pre-ribosomes. Using fold recognition and structural modeling, we show that Noc1-4p are largely comprised of alpha-helical repeats similar to HEAT repeats. Because other HEAT-repeat proteins play key roles in transport processes, this finding provides a plausible mechanistic explanation for the function of the Noc proteins.

SUBMITTER: Dlakic M 

PROVIDER: S-EPMC1370930 | biostudies-literature | 2004 Mar

REPOSITORIES: biostudies-literature

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The Noc proteins involved in ribosome synthesis and export contain divergent HEAT repeats.

Dlakić Mensur M   Tollervey David D  

RNA (New York, N.Y.) 20040301 3

The Noc1-4p proteins were previously reported to be involved in intranuclear and nucleocytoplasmic transport of pre-ribosomes. Using fold recognition and structural modeling, we show that Noc1-4p are largely comprised of alpha-helical repeats similar to HEAT repeats. Because other HEAT-repeat proteins play key roles in transport processes, this finding provides a plausible mechanistic explanation for the function of the Noc proteins. ...[more]

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