Prediction of consensus structural motifs in a family of coregulated RNA sequences.

ABSTRACT: Given a set of homologous or functionally related RNA sequences, the consensus motifs may represent the binding sites of RNA regulatory proteins. Unlike DNA motifs, RNA motifs are more conserved in structures than in sequences. Knowing the structural motifs can help us gain a deeper insight of the regulation activities. There have been various studies of RNA secondary structure prediction, but most of them are not focused on finding motifs from sets of functionally related sequences. Although recent research shows some new approaches to RNA motif finding, they are limited to finding relatively simple structures, e.g. stem-loops. In this paper, we propose a novel genetic programming approach to RNA secondary structure prediction. It is capable of finding more complex structures than stem-lo

SUBMITTER: Hu YJ 

PROVIDER: S-EPMC137409 | biostudies-literature | 2002 Sep

REPOSITORIES: biostudies-literature