Gene expression comparison of biopsies from Duchenne muscular dystrophy (DMD) and normal skeletal muscle.

ABSTRACT: The primary cause of Duchenne muscular dystrophy (DMD) is a mutation in the dystrophin gene leading to the absence of the corresponding RNA transcript and protein. Absence of dystrophin leads to disruption of the dystrophin-associated protein complex and substantial changes in skeletal muscle pathology. Although the histological pathology of dystrophic tissue has been well documented, the underlying molecular pathways remain poorly understood. To examine the pathogenic pathways and identify new or modifying factors involved in muscular dystrophy, expression microarrays were used to compare individual gene expression profiles of skeletal muscle biopsies from 12 DMD patients and 12 unaffected control patients. Two separate statistical analysis methods were used to interpret the resulting dat

SUBMITTER: Haslett JN 

PROVIDER: S-EPMC137534 | biostudies-literature | 2002 Nov

REPOSITORIES: biostudies-literature