Domain-oriented functional analysis based on expression profiling.

ABSTRACT:

Background

Co-regulation of genes may imply involvement in similar biological processes or related function. Many clusters of co-regulated genes have been identified using microarray experiments. In this study, we examined co-regulated gene families using large-scale cDNA microarray experiments on the human transcriptome.

Results

We present a simple model, which, for each probe pair, distills expression changes into binary digits and summarizes the expression of multiple members of a gene family as the Family Regulation Ratio. The set of Family Regulation Ratios for each protein family across multiple experiments is called a Family Regulation Profile. We analyzed these Family Regulation Profiles using Pearson Correlation Coefficients and derived a network diagram portraying

SUBMITTER: Ding W 

PROVIDER: S-EPMC137579 | biostudies-literature | 2002 Oct

REPOSITORIES: biostudies-literature