Spike timing in CA3 pyramidal cells during behavior: implications for synaptic transmission.

ABSTRACT: Spike timing is thought to be an important mechanism for transmitting information in the CNS. Recent studies have emphasized millisecond precision in spike timing to allow temporal summation of rapid synaptic signals. However, spike timing over slower time scales could also be important, through mechanisms including activity-dependent synaptic plasticity or temporal summation of slow postsynaptic potentials (PSPs) such as those mediated by kainate receptors. To determine the extent to which these slower mechanisms contribute to information processing, it is first necessary to understand the properties of behaviorally relevant spike timing over this slow time scale. In this study, we examine the activity of CA3 pyramidal cells during the performance of a complex behavioral task in rats. Sus

SUBMITTER: Frerking M 

PROVIDER: S-EPMC1378104 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature