A Drosophila dopamine 2-like receptor: Molecular characterization and identification of multiple alternatively spliced variants.

ABSTRACT: Dopamine is an important neurotransmitter in the central nervous system of both Drosophila and mammals. Despite the evolutionary distance, functional parallels exist between the fly and mammalian dopaminergic systems, with both playing roles in modulating locomotor activity, sexual function, and the response to drugs of abuse. In mammals, dopamine exerts its effects through either dopamine 1-like (D1-like) or D2-like G protein-coupled receptors. Although pharmacologic data suggest the presence of both receptor subtypes in insects, only cDNAs encoding D1-like proteins have been isolated previously. Here we report the cloning and characterization of a newly discovered Drosophila dopamine receptor. Sequence analysis reveals that this putative protein shares highest homology with known mammali

SUBMITTER: Hearn MG 

PROVIDER: S-EPMC137921 | biostudies-literature | 2002 Oct

REPOSITORIES: biostudies-literature