A testing framework for identifying susceptibility genes in the presence of epistasis.

ABSTRACT: An efficient testing strategy called the "focused interaction testing framework" (FITF) was developed to identify susceptibility genes involved in epistatic interactions for case-control studies of candidate genes. In the FITF approach, likelihood-ratio tests are performed in stages that increase in the order of interaction considered. Joint tests of main effects and interactions are performed conditional on significant lower-order effects. A reduction in the number of tests performed is achieved by prescreening gene combinations with a goodness-of-fit chi2 statistic that depends on association among candidate genes in the pooled case-control group. Multiple testing is accounted for by controlling false-discovery rates. Simulation analysis demonstrated that the FITF approach is more powerf

SUBMITTER: Millstein J 

PROVIDER: S-EPMC1380213 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature