A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.

ABSTRACT: Strong evidence of linkage to late-onset Alzheimer disease (LOAD) has been observed on chromosome 10, which implicates a wide region and at least one disease-susceptibility locus. Although significant associations with several biological candidate genes on chromosome 10 have been reported, these findings have not been consistently replicated, and they remain controversial. We performed a chromosome 10-specific association study with 1,412 gene-based single-nucleotide polymorphisms (SNPs), to identify susceptibility genes for developing LOAD. The scan included SNPs in 677 of 1,270 known or predicted genes; each gene contained one or more markers, about half (48%) of which represented putative functional mutations. In general, the initial testing was performed in a white case-control sample

SUBMITTER: Grupe A 

PROVIDER: S-EPMC1380225 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature