Regulation of the human LAT gene by the Elf-1 transcription factor.

ABSTRACT:

Background

The LAT gene encodes an intracellular adaptor protein that links cell-surface receptor engagement to numerous downstream signalling events, and thereby plays an integral role in the function of cell types that express the gene, including T cells, mast cells, natural killer cells, and platelets. To date, the mechanisms responsible for the transcriptional regulation of this gene have not been investigated.

Results

In this study we have mapped the transcriptional start sites for the human LAT gene and localized the 5' and 3' boundaries of the proximal promoter. We find that the promoter contains both positive and negative regulatory regions, and that two binding sites for the Ets family of transcription factors have a strong, positive effect on gene expression. Each

SUBMITTER: Finco TS 

PROVIDER: S-EPMC1382244 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature