Analysis of case-parent trios at a locus with a deletion allele: association of GSTM1 with autism.

ABSTRACT:

Background

Certain loci on the human genome, such as glutathione S-transferase M1 (GSTM1), do not permit heterozygotes to be reliably determined by commonly used methods. Association of such a locus with a disease is therefore generally tested with a case-control design. When subjects have already been ascertained in a case-parent design however, the question arises as to whether the data can still be used to test disease association at such a locus.

Results

A likelihood ratio test was constructed that can be used with a case-parents design but has somewhat less power than a Pearson's chi-squared test that uses a case-control design. The test is illustrated on a novel dataset showing a genotype relative risk near 2 for the homozygous GSTM1 deletion genotype and autism.

Co

SUBMITTER: Buyske S 

PROVIDER: S-EPMC1382247 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature