Dendritic mRNAs encode diversified functionalities in hippocampal pyramidal neurons.

ABSTRACT:

Background

Targeted transport of messenger RNA and local protein synthesis near the synapse are important for synaptic plasticity. In order to gain an overview of the composition of the dendritic mRNA pool, we dissected out stratum radiatum (dendritic lamina) from rat hippocampal CA1 region and compared its mRNA content with that of stratum pyramidale (cell body layer) using a set of cDNA microarrays. RNAs that have over-representation in the dendritic fraction were annotated and sorted into function groups.

Results

We have identified 154 dendritic mRNA candidates, which can be arranged into the categories of receptors and channels, signaling molecules, cytoskeleton and adhesion molecules, and factors that are involved in membrane trafficking, in protein synthesis, in posttr

SUBMITTER: Zhong J 

PROVIDER: S-EPMC1386695 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature