The in vitro real-time oscillation monitoring system identifies potential entrainment factors for circadian clocks.

ABSTRACT:

Background

Circadian rhythms are endogenous, self-sustained oscillations with approximately 24-hr rhythmicity that are manifested in various physiological and metabolic processes. The circadian organization of these processes in mammals is governed by the master oscillator within the suprachiasmatic nuclei (SCN) of the hypothalamus. Recent findings revealed that circadian oscillators exist in most organs, tissues, and even in immortalized cells, and that the oscillators in peripheral tissues are likely to be coordinated by SCN, the master oscillator. Some candidates for endogenous entrainment factors have sporadically been reported, however, their details remain mainly obscure.

Results

We developed the in vitro real-time oscillation monitoring system (IV-ROMS) by measuring t

SUBMITTER: Nakahata Y 

PROVIDER: S-EPMC1386696 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature