Discovery of Time-Delayed Gene Regulatory Networks based on temporal gene expression profiling.

ABSTRACT:

Background

It is one of the ultimate goals for modern biological research to fully elucidate the intricate interplays and the regulations of the molecular determinants that propel and characterize the progression of versatile life phenomena, to name a few, cell cycling, developmental biology, aging, and the progressive and recurrent pathogenesis of complex diseases. The vast amount of large-scale and genome-wide time-resolved data is becoming increasing available, which provides the golden opportunity to unravel the challenging reverse-engineering problem of time-delayed gene regulatory networks.

Results

In particular, this methodological paper aims to reconstruct regulatory networks from temporal gene expression data by using delayed correlations between genes, i.e., pairwi

SUBMITTER: Li X 

PROVIDER: S-EPMC1386718 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature