The Epc-N domain: a predicted protein-protein interaction domain found in select chromatin associated proteins.

ABSTRACT:

Background

An underlying tenet of the epigenetic code hypothesis is the existence of protein domains that can recognize various chromatin structures. To date, two major candidates have emerged: (i) the bromodomain, which can recognize certain acetylation marks and (ii) the chromodomain, which can recognize certain methylation marks.

Results

The Epc-N (Enhancer of Polycomb-N-terminus) domain is formally defined herein. This domain is conserved across eukaryotes and is predicted to form a right-handed orthogonal four-helix bundle with extended strands at both termini. The types of amino acid residues that define the Epc-N domain suggest a role in mediating protein-protein interactions, possibly specifically in the context of chromatin binding, and the types of proteins in whic

SUBMITTER: Perry J 

PROVIDER: S-EPMC1388200 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature