Early adult-onset POAG linked to 15q11-13 using ordered subset analysis.

ABSTRACT:

Purpose

Primary open-angle glaucoma (POAG) is a complex inherited disorder. It has been demonstrated in other complex disorders that phenotypic heterogeneity may be the result of genetic heterogeneity and that stratification analysis can be used to increase the power of detection. Ordered subset analysis (OSA) is a recently described method that utilizes the variability of phenotypic traits to determine underlying genetic heterogeneity.

Methods

Eighty-six multiplex families with POAG were clinically ascertained for genetic analysis. Age at diagnosis (AAD) was used as a surrogate for age of onset in affected family members. Nine genetic markers within the 15q11-13 interval on chromosome 15 were used for OSA analysis.

Results

An 11-cM linkage interval with a peak LOD sc

SUBMITTER: Allingham RR 

PROVIDER: S-EPMC1389566 | biostudies-literature | 2005 Jun

REPOSITORIES: biostudies-literature