An evaluation of the performance of tag SNPs derived from HapMap in a Caucasian population.

ABSTRACT: The Haplotype Map (HapMap) project recently generated genotype data for more than 1 million single-nucleotide polymorphisms (SNPs) in four population samples. The main application of the data is in the selection of tag single-nucleotide polymorphisms (tSNPs) to use in association studies. The usefulness of this selection process needs to be verified in populations outside those used for the HapMap project. In addition, it is not known how well the data represent the general population, as only 90-120 chromosomes were used for each population and since the genotyped SNPs were selected so as to have high frequencies. In this study, we analyzed more than 1,000 individuals from Estonia. The population of this northern European country has been influenced by many different waves of migrations f

SUBMITTER: Montpetit A 

PROVIDER: S-EPMC1391920 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature