Highly variable rates of genome rearrangements between hemiascomycetous yeast lineages.

ABSTRACT: Hemiascomycete yeasts cover an evolutionary span comparable to that of the entire phylum of chordates. Since this group currently contains the largest number of complete genome sequences it presents unique opportunities to understand the evolution of genome organization in eukaryotes. We inferred rates of genome instability on all branches of a phylogenetic tree for 11 species and calculated species-specific rates of genome rearrangements. We characterized all inversion events that occurred within synteny blocks between six representatives of the different lineages. We show that the rates of macro- and microrearrangements of gene order are correlated within individual lineages but are highly variable across different lineages. The most unstable genomes correspond to the pathogenic yeasts C

SUBMITTER: Fischer G 

PROVIDER: S-EPMC1391921 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature