Stable evolutionary signal in a yeast protein interaction network.

ABSTRACT:

Background

The recently emerged protein interaction network paradigm can provide novel and important insights into the innerworkings of a cell. Yet, the heavy burden of both false positive and false negative protein-protein interaction data casts doubt on the broader usefulness of these interaction sets. Approaches focusing on one-protein-at-a-time have been powerfully employed to demonstrate the high degree of conservation of proteins participating in numerous interactions; here, we expand his 'node' focused paradigm to investigate the relative persistence of 'link' based evolutionary signals in a protein interaction network of S. cerevisiae and point out the value of this relatively untapped source of information.

Results

The trend for highly connected proteins to be prefe

SUBMITTER: Wuchty S 

PROVIDER: S-EPMC1395346 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature