Modelling the impact of antiretroviral use in resource-poor settings.

ABSTRACT:

Background

The anticipated scale-up of antiretroviral therapy (ART) in high-prevalence, resource-constrained settings requires operational research to guide policy on the design of treatment programmes. Mathematical models can explore the potential impacts of various treatment strategies, including timing of treatment initiation and provision of laboratory monitoring facilities, to complement evidence from pilot programmes.

Methods and findings

A deterministic model of HIV transmission incorporating ART and stratifying infection progression into stages was constructed. The impact of ART was evaluated for various scenarios and treatment strategies, with different levels of coverage, patient eligibility, and other parameter values. These strategies included the provision of la

SUBMITTER: Baggaley RF 

PROVIDER: S-EPMC1395349 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature