Subcellular localization of hepatitis C virus structural proteins in a cell culture system that efficiently replicates the virus.

ABSTRACT: Due to the recent development of a cell culture model, hepatitis C virus (HCV) can be efficiently propagated in cell culture. This allowed us to reinvestigate the subcellular localization of HCV structural proteins in the context of an infectious cycle. In agreement with previous reports, confocal immunofluorescence analysis of the subcellular localization of HCV structural proteins indicated that, in infected cells, the glycoprotein heterodimer is retained in the endoplasmic reticulum. However, in contrast to other studies, the glycoprotein heterodimer did not accumulate in other intracellular compartments or at the plasma membrane. As previously reported, an association between the capsid protein and lipid droplets was also observed. In addition, a fraction of labeling was consistent wit

SUBMITTER: Rouille Y 

PROVIDER: S-EPMC1395453 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature