Population-based neuropathological studies of dementia: design, methods and areas of investigation--a systematic review.

ABSTRACT:

Background

Prospective population-based neuropathological studies have a special place in dementia research which is under emphasised.

Methods

A systematic review of the methods of population-based neuropathological studies of dementia was carried out. These studies were assessed in relation to their representativeness of underlying populations and the clinical, neuropsychological and neuropathological approaches adopted.

Results

Six studies were found to be true population-based neuropathological studies of dementia in the older people: the Hisayama study (Japan); Vantaa 85+ study (Finland); CC75C study (Cambridge, UK); CFAS (multicentre, UK); Cache County study (Utah, USA); HAAS (Hawaï, USA). These differ in the core characteristics of their populations. The studies

SUBMITTER: Zaccai J 

PROVIDER: S-EPMC1397861 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature