Efficient synthesis of 5-substituted 2-aryl-6-cyanoindolizines via nucleophilic substitution reactions.

ABSTRACT: 2-Aryl-6-cyano-7-methyl-5-indolizinones were successfully converted into 2-aryl-5-chloro-6-cyano-7-methylindolizines. The obtained 5-chloroindolizines readily underwent nucleophilic substitution at position 5 leading in high yields to novel 5-functionalised indolizines.

SUBMITTER: Babaev EV 

PROVIDER: S-EPMC1399457 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature