Intrastrain and interstrain genetic variation within a paralogous gene family in Chlamydia pneumoniae.

ABSTRACT: BACKGROUND:Chlamydia pneumoniae causes human respiratory diseases and has recently been associated with atherosclerosis. Analysis of the three recently published C. pneumoniae genomes has led to the identification of a new gene family (the Cpn 1054 family) that consists of 11 predicted genes and gene fragments. Each member encodes a polypeptide with a hydrophobic domain characteristic of proteins localized to the inclusion membrane. RESULTS:Comparative analysis of this gene family within the published genome sequences provided evidence that multiple levels of genetic variation are evident within this single collection of paralogous genes. Frameshift mutations are found that result in both truncated gene products and pseudogenes that vary among isolates. Several genes in this family contain

SUBMITTER: Viratyosin W 

PROVIDER: S-EPMC140016 | biostudies-literature | 2002 Dec

REPOSITORIES: biostudies-literature