Form deprivation modulates retinal neurogenesis in primate experimental myopia.

ABSTRACT: Juvenile primates develop myopia when their visual experience is degraded by lid fusion. In response to this abnormal visual input, retinal neural networks cause an excessive growth of the postequatorial segment of the eye, but the mechanism underlying this axial elongation is unknown. After fusion of the lids in one eye of juvenile rhesus macaques and green monkeys, we combined cDNA subtractions, microarray profiling, and real-time PCR to compare gene expression in the retinas of the closed and open eyes. This molecular analysis showed up-regulation of a number of genes associated with cell division in the retina of the closed eye and differential expression of six genes localized to chromosomal loci linked to forms of human hereditary myopia. In addition, it substantiated a previous obse

SUBMITTER: Tkatchenko AV 

PROVIDER: S-EPMC1400590 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature