No relationship between sequence variation in protein coding regions of the Tas1r3 gene and saccharin preference in rats.

ABSTRACT: Nearly all mammalian species like sweet-tasting foods and drinks, but there are differences in the degree of 'sweet tooth' both between species and among individuals of the same species. Some individual differences can be explained by genetic variability. Polymorphisms in a sweet taste receptor (Tas1r3) account for a large fraction of the differences in consumption of sweet solutions among inbred mouse strains. We wondered whether mice and rats share the same Tas1r3 alleles, and whether this gene might explain the large difference in saccharin preference among rats. We conducted three experiments to test this. We examined DNA sequence differences in the Tas1r3 gene among rats that differed in their consumption of saccharin in two-bottle choice tests. The animals tested were from an outbred

SUBMITTER: Lu K 

PROVIDER: S-EPMC1400602 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature