Borna disease virus blocks potentiation of presynaptic activity through inhibition of protein kinase C signaling.

ABSTRACT: Infection by Borna disease virus (BDV) enables the study of the molecular mechanisms whereby a virus can persist in the central nervous system and lead to altered brain function in the absence of overt cytolysis and inflammation. This neurotropic virus infects a wide variety of vertebrates and causes behavioral diseases. The basis of BDV-induced behavioral impairment remains largely unknown. Here, we investigated whether BDV infection of neurons affected synaptic activity, by studying the rate of synaptic vesicle (SV) recycling, a good indicator of synaptic activity. Vesicular cycling was visualized in cultured hippocampal neurons synapses, using an assay based on the uptake of an antibody directed against the luminal domain of synaptotagmin I. BDV infection did not affect elementary presy

SUBMITTER: Volmer R 

PROVIDER: S-EPMC1401496 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature