HFE H63D mutation frequency shows an increase in Turkish women with breast cancer.

ABSTRACT:

Background

The hereditary hemochromatosis gene HFE plays a pivotal role in iron homeostasis. The association between cancer and HFE hetero- or homozygosity has previously been shown including hepatocellular and nonhepatocellular malignancies. This study was performed to compare frequencies of HFE C282Y and H63D variants in Turkish women with breast cancer and healthy controls.

Methods

Archived DNA samples of Hacettepe University Oncology Institute were used in this study. The HFE gene was investigated by PCR-RFLP.

Results

All subjects studied were free from C282Y mutation. Thirty-nine patients had H63D mutation and were all heterozygous. H63D allele frequency was 22.2% (39/176) in the breast cancer patients, and 14% (28/200) in the healthy volunteers. Statistical anal

SUBMITTER: Gunel-Ozcan A 

PROVIDER: S-EPMC1402308 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature