Higher transactivation activity associated with LTR and Tat elements from HIV-1 BF intersubtype recombinant variants.

ABSTRACT:

Background

HIV-1 is characterized by its rapid genetic evolution and high diversity as a consequence of its error-prone reverse transcriptase and genetic recombination. This latter mechanism is responsible for the creation of circulating recombinant forms (CRFs) found in nature. Previous studies from our lab group have shown that the epidemic in Argentina is characterized by one highly prevalent circulating recombinant form, CRF12_BF, and many related BF recombinant forms. Since transcriptional transactivation of the HIV-1 long terminal repeat (LTR) promoter element requires the essential viral Tat protein, since these genetic structures underwent recombination in variants widely spread in South America, the aim of this work was to study transcriptional activity associated with the

SUBMITTER: Turk G 

PROVIDER: S-EPMC1402313 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature