Phase analysis of circadian-related genes in two tissues.

ABSTRACT:

Background

Recent circadian clock studies using gene expression microarray in two different tissues of mouse have revealed not all circadian-related genes are synchronized in phase or peak expression times across tissues in vivo. Instead, some circadian-related genes may be delayed by 4-8 hrs in peak expression in one tissue relative to the other. These interesting biological observations prompt a statistical question regarding how to distinguish the synchronized genes from genes that are systematically lagged in phase/peak expression time across two tissues.

Results

We propose a set of techniques from circular statistics to analyze phase angles of circadian-related genes in two tissues. We first estimate the phases of a cycling gene separately in each tissue, which are then

SUBMITTER: Liu D 

PROVIDER: S-EPMC1403809 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature