Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts.

ABSTRACT:

Introduction

Adjuvant breast cancer therapy significantly improves survival, but overtreatment and undertreatment are major problems. Breast cancer expression profiling has so far mainly been used to identify women with a poor prognosis as candidates for adjuvant therapy but without demonstrated value for therapy prediction.

Methods

We obtained the gene expression profiles of 159 population-derived breast cancer patients, and used hierarchical clustering to identify the signature associated with prognosis and impact of adjuvant therapies, defined as distant metastasis or death within 5 years. Independent datasets of 76 treated population-derived Swedish patients, 135 untreated population-derived Swedish patients and 78 Dutch patients were used for validation. The inclusion a

SUBMITTER: Pawitan Y 

PROVIDER: S-EPMC1410752 | biostudies-literature | 2005

REPOSITORIES: biostudies-literature