Offline persistence of memory-related cerebral activity during active wakefulness.

ABSTRACT: Much remains to be discovered about the fate of recent memories in the human brain. Several studies have reported the reactivation of learning-related cerebral activity during post-training sleep, suggesting that sleep plays a role in the offline processing and consolidation of memory. However, little is known about how new information is maintained and processed during post-training wakefulness before sleep, while the brain is actively engaged in other cognitive activities. We show, using functional magnetic resonance imaging, that brain activity elicited during a new learning episode modulates brain responses to an unrelated cognitive task, during the waking period following the end of training. This post-training activity evolves in learning-related cerebral structures, in which functio

SUBMITTER: Peigneux P 

PROVIDER: S-EPMC1413571 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature