Buffering of crucial functions by paleologous duplicated genes may contribute cyclicality to angiosperm genome duplication.

ABSTRACT: Genome duplication followed by massive gene loss has permanently shaped the genomes of many higher eukaryotes, particularly angiosperms. It has long been believed that a primary advantage of genome duplication is the opportunity for the evolution of genes with new functions by modification of duplicated genes. If so, then patterns of genetic diversity among strains within taxa might reveal footprints of selection that are consistent with this advantage. Contrary to classical predictions that duplicated genes may be relatively free to acquire unique functionality, we find among both Arabidopsis ecotypes and Oryza subspecies that SNPs encode less radical amino acid changes in genes for which there exists a duplicated copy at a "paleologous" locus than in "singleton" genes. Preferential reten

SUBMITTER: Chapman BA 

PROVIDER: S-EPMC1413778 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature