Gene expression patterns in dendritic cells infected with measles virus compared with other pathogens.

ABSTRACT: Gene expression patterns supply insight into complex biological networks that provide the organization in which viruses and host cells interact. Measles virus (MV) is an important human pathogen that induces transient immunosuppression followed by life-long immunity in infected individuals. Dendritic cells (DCs) are potent antigen-presenting cells that initiate the immune response to pathogens and are postulated to play a role in MV-induced immunosuppression. To better understand the interaction of MV with DCs, we examined the gene expression changes that occur over the first 24 h after infection and compared these changes to those induced by other viral, bacterial, and fungal pathogens. There were 1,553 significantly regulated genes with nearly 60% of them down-regulated. MV-infected DCs

SUBMITTER: Zilliox MJ 

PROVIDER: S-EPMC1413941 | biostudies-literature | 2006 Feb

REPOSITORIES: biostudies-literature