A systematic model to predict transcriptional regulatory mechanisms based on overrepresentation of transcription factor binding profiles.

ABSTRACT: An important aspect of understanding a biological pathway is to delineate the transcriptional regulatory mechanisms of the genes involved. Two important tasks are often encountered when studying transcription regulation, i.e., (1) the identification of common transcriptional regulators of a set of coexpressed genes; (2) the identification of genes that are regulated by one or several transcription factors. In this study, a systematic and statistical approach was taken to accomplish these tasks by establishing an integrated model considering all of the promoters and characterized transcription factors (TFs) in the genome. A promoter analysis pipeline (PAP) was developed to implement this approach. PAP was tested using coregulated gene clusters collected from the literature. In most test cas

SUBMITTER: Chang LW 

PROVIDER: S-EPMC1415218 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature