Effect of matrine and carvedilol on collagen and MMPs activity of hypertrophy myocardium induced by pressure overload.

ABSTRACT:

Objective

To explore the effect and mechanism of matrine (Mt.) on myocardial interstitial fibrosis induced by pressure overload.

Methods

Pressure overloaded myocardial hypertrophy was produced by banding of aorta abdominalis in 67 male Sprague-Dawley rats weighing (200+/-15) g. The rats were assigned into one of the following groups: sham-operation control, operation control, operation group treated with matrine (15 mg/(kg.d)) and treated with carvedilol (Car.) (3.6 mg/(kg.d)) group. The rats were given drugs one day after operation. Five weeks after treatment, the left ventricular weight (LVW) was measured and the volume of myocardial cells was detected with Hematoxylin-Eosin (H-E) stain and Masson stain was used to assess the level of fibrosis of the myocardial matrix. Myo

SUBMITTER: Zhang YJ 

PROVIDER: S-EPMC1419068 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature