Lower expression of genes near microRNA in C. elegans germline.

ABSTRACT:

Background

MicroRNAs (miRNAs) are recently discovered short non-protein-coding RNA molecules. miRNAs are increasingly implicated in tissue-specific transcriptional control and particularly in development. Because there is mounting evidence for the localized component of transcriptional control, we investigated if there is a distance-dependent effect of miRNA.

Results

We analyzed gene expression levels around the 84 of 113 know miRNAs for which there are nearby gene that were measured in the data in two independent C. elegans expression data sets. The expression levels are lower for genes in the vicinity of 59 of 84 (71%) miRNAs as compared to genes far from such miRNAs. Analysis of the genes with lower expression in proximity to the miRNAs reveals increased frequency matchin

SUBMITTER: Inaoka H 

PROVIDER: S-EPMC1420334 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature