Different papillomaviruses have different repertoires of transcription factor binding sites: convergence and divergence in the upstream regulatory region.

ABSTRACT:

Background

Papillomaviruses (PVs) infect stratified squamous epithelia in warm-blooded vertebrates and have undergone a complex evolutionary process. The control of the expression of the early ORFs in PVs depends on the binding of cellular and viral transcription factors to the upstream regulatory region (URR) of the virus. It is believed that there is a core of transcription factor binding sites (TFBS) common to all PVs, with additional individual differences, although most of the available information focuses only on a handful of viruses.

Results

We have studied the URR of sixty-one PVs, covering twenty different hosts. We have predicted the TFBS present in the URR and analysed these results by principal component analysis and genetic algorithms. The number and nature of T

SUBMITTER: Garcia-Vallve S 

PROVIDER: S-EPMC1421437 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature