The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.

ABSTRACT: Sox proteins are widely believed to team up with other transcription factors as partner proteins to perform their many essential functions during development. In this study, yeast two-hybrid screens identified transcription factors as a major group of interacting proteins for Sox8 and Sox10. Interacting transcription factors were very similar for these two group E Sox proteins and included proteins with different types of DNA-binding domains, such as homeodomain proteins, zinc finger proteins, basic helix-loop-helix and leucine zipper proteins. In all cases analyzed, the interaction involved the DNA-binding domain of the transcription factor which directly contacted the C-terminal part of the high-mobility-group (HMG) domain. In particular, the C-terminal tail region behind helix 3 of the

SUBMITTER: Wissmuller S 

PROVIDER: S-EPMC1421504 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature