A caulobacter crescentus extracytoplasmic function sigma factor mediating the response to oxidative stress in stationary phase.

ABSTRACT: Alternative sigma factors of the extracytoplasmic function (ECF) subfamily are important regulators of stress responses in bacteria and have been implicated in the control of homeostasis of the extracytoplasmic compartment of the cell. This work describes the characterization of sigF, encoding 1 of the 13 members of this subfamily identified in Caulobacter crescentus. A sigF-null strain was obtained and shown to be severely impaired in resistance to oxidative stress, caused by hydrogen peroxide treatment, exclusively during the stationary phase. Although sigF mRNA levels decrease in stationary-phase cells, the amount of sigma(F) protein is greatly increased at this stage, indicating a posttranscriptional control. Data obtained indicate that the FtsH protease is either directly or indirectl

SUBMITTER: Alvarez-Martinez CE 

PROVIDER: S-EPMC1426549 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature