Effects of streptomycin resistance mutations on posttranslational modification of ribosomal protein S12.

ABSTRACT: Ribosomal protein S12 contains a highly conserved aspartic acid residue that is posttranslationally beta-methylthiolated. Using mass spectrometry, we have determined the modification states of several S12 mutants of Thermus thermophilus and conclude that beta-methylthiolation is not a determinant of the streptomycin phenotype.

SUBMITTER: Carr JF 

PROVIDER: S-EPMC1426572 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature